Product Description of 1-Methylpiperazine CAS#109-01-3
1-Methylpiperazine is a clear, colorless amine liquid with a molecular formula of C₅H₁₂N₂ and a molecular weight of 100.16. It has a boiling point of 138 °C, a relative density of 0.903 g/mL (20/4 °C), and a standard refractive index of 1.466, with a flash point of 42 °C.
This compound is fully miscible with water, methanol, ethanol and ether in any proportion. Its aqueous solution presents weak alkalinity with a pH range of 11–12. Characterized by hygroscopicity, it requires sealed preservation against moisture. It is a fundamental nitrogen-heterocyclic intermediate widely used in fine chemical and pharmaceutical synthesis.
1-Methylpiperazine Chemical Properties
| Melting point | -6 °C |
| Boiling point | 138 °C(lit.) |
| density | 0.903 g/mL at 25 °C(lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 12 hPa (20 °C) |
| refractive index | n20/D 1.466(lit.) |
| Fp | 108 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Methanol (Soluble) |
| pka | pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1) |
| form | Liquid |
| color | Clear |
| Specific Gravity | 0.903 |
| PH | 11-12 (50g/l, H2O, 20℃) |
| explosive limit | 1.2-9.9%(V) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 102724 |
| InChIKey | PVOAHINGSUIXLS-UHFFFAOYSA-N |
| LogP | -0.57 at 25℃ |
| CAS DataBase Reference | 109-01-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperazine, 1-methyl-(109-01-3) |
| EPA Substance Registry System | Piperazine, 1-methyl- (109-01-3) |
| Hazard Codes | T,F,C,Xi |
| Risk Statements | 10-21-23-34-36/37/38-20/21 |
| Safety Statements | 16-26-36/37/39-45-36 |
| RIDADR | UN 2734 8/PG 2 |
| WGK Germany | 2 |
| RTECS | TM1225000 |
| Autoignition Temperature | 320 °C |
| Hazard Note | Flammable/Toxic/Corrosive/Store under nitrogen |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29335995 |
| Toxicity | LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg |
Product Application of 1-Methylpiperazine CAS#109-01-3
1-Methylpiperazine is a versatile nitrogen-heterocyclic building block widely applied in organic synthesis and modern pharmaceutical manufacturing. Its active amine structure enables efficient modification reactions, supporting the development of multiple high-value drug molecules.
It serves as a core intermediate for synthesizing antibiotics including ofloxacin, as well as antipsychotic agents such as trifluoperazine, clozapine and zopiclone. Moreover, it is essential for the production of sildenafil and other bioactive APIs. Beyond pharmaceutical manufacturing, this compound is extensively utilized in pesticides, dyes, plastics and other fine chemical industries for diverse synthetic processes.
