Products Description of Atorvastatin Intermediate M4 CAS#125971-96-2
Atorvastatin Intermediate M4 (CAS#125971-96-2), also named 4-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenylbenzenebutanamide, With the molecular formula C26H24FNO3 and molecular-weight of 417.47, this high-grade pharmaceutical intermediate serves as the indispensable building-block for manufacturing lipid-lowering atorvastatin-calcium. The pure-grade substance appears as white to off-white crystalline powder under ambient conditions. It dissolves well in common organic solvents while barely dissolving in cold-water. Sealed, cool and dark storage can preserve its chemical stability for long-term synthetic work of atorvastatin finished-product.
Atorvastatin Intermediate M4 Chemical Properties
| English Name | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
| English Synonyms | M-4:2[2-(4-FLUOROPHENYL)-2-OXO-1-PHENYLETHYL]-4-METHYL-3-OXO-PENTANOIC ACID PHENYLAMID E;4-FLUORO-ALPHA-(2-METHYL-1-OXOPROPYL-GAMA-OXO)-N,BETA-DIPHENYLBENZENE BUTANEAMIDE; 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL-GAMMA(3)-OXO]-N,BETA-DIPHENYLBENZENE BUTANE AMI DE:4-fluoro-alpha-(2-methyl-1-oxopropyl)-gamma-oxo-n,bata-diphenylbenzene butaneamide;4-FLUOROALPHA-(2-METHYL-1-OXOPROPYL)-GAMMA-OXO-N, BETA-DIPHENYLBENZENE BUTANAMIDE;4-fluoro-α(2-methyl-1-oxo-propyl)-y-oxo-N-β-diphenyl benzene butanamide;(4-fluoro-a-[2-methyl-1-oxopropyl]-yoxo-N,β-diphenylbenzene butane amide(M-4) |
| CAS Number | 125971-96-2 |
| Molecular Formula | C26H24FNO3 |
| Molecular Weight | 417.47 |
| EINECS Number | 603-107-6 |
| Melting point | 196-1980С |
| Boiling point | 631.4±55.0 °C(Predicted) |
| Density | 1.211 |
| Storage conditions | Sealed in dry,2-8°C |
| Solubility | Chloroform (dissolves slightly, upon heating), DMSO (dissolves slightly, upon sonication), ethyl acetate (dissolves slightly). |
| Acidity coefficient (pKa) | 11.52±0.59(Predicted) |
| Form | solid |
| Color | White to off-white |
| pH value | 6.49 at 25℃ and 13.64g/L |
| InChI | InCh=1S/C26H24FNO3/c1-17(2)24(29)23(26(31)28-21-11-7-4-8-12-21)22(18-9-5-3-6-10-18)25(30)19-1315-20(27)16-14-19/h3-17,22-23H,1-2H3,(H,28,31) |
| InChIKey | SNPBHOICIJUUFB-UHFFFAOYSA-N |
| Smiles | C(NC1=CC=CC=C1)(=O)C(C(C1=CC=CC=C1)C(C1=CC=C(F)C=C1)=0)C(=O)C(C)C |
Product Application of Atorvastatin Intermediate M4 CAS#125971-96-2
Atorvastatin Intermediate M4 functions as a vital fine-chemical raw-material for the commercial-scale production of atorvastatin-calcium active-pharmaceutical-ingredient.
It supplies the required carbon skeleton throughout the multi-step synthetic workflow. Its ketone carbonyl functional group is capable of carrying out condensation reactions with amine-containing substances. Such chemical conversion helps construct pyrrole-ring frameworks, which constitute one indispensable structural segment of the finished cholesterol-lowering medicine.
