Product Description of D-(-)-Pantolactone CAS#599-04-2
D-(-)-Pantolactone is a moisture-absorbing crystalline substance. It can be purified via recrystallization in benzene and petroleum ether mixed solvents or through sublimation treatment. This chemical features a melting point of 80–92°C and a boiling point of 130°C under a pressure of 2.4 kPa.
It boasts excellent solubility in water and is also miscible with a wide range of organic solvents, such as ethanol, diethyl ether, chloroform, carbon disulfide and benzene.
Structurally differentiated isomers show distinct physicochemical parameters. The R-isomer has a melting point of 92°C and a specific optical rotation of [α]D −50.7° (C = 2.05, H₂O). In comparison, the S-isomer delivers a melting point of 91°C and a specific optical rotation of [α]D +50° (C = 2.00, H₂O).
D-(-)-PANTOLACTONE Chemical Properties
| Melting point | 91 °C(lit.) |
| Boiling point | 120-122 °C15 mm Hg(lit.) |
| density | 1.1066 (rough estimate) |
| vapor pressure | 0.3-3.28Pa at 15-35℃ |
| refractive index | -50.8 ° (C=2, H2O) |
| Fp | 120-122°C/15mm |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly) |
| form | Crystals or Crystalline Powder |
| pKa | 13.12±0.40(Predicted) |
| color | White |
| Odor | cotton candy |
| optical activity | [α]25/D 49.8°, c = 2 in H2O |
| Water Solubility | almost transparency |
| Sensitive | Hygroscopic |
| Merck | 147013 |
| BRN | 80957 |
| InChIKey | SERHXTVXHNVDKA-BYPYZUCNSA-N |
| LogP | -0.973--0.46 at 22.5-25℃ and pH7.1 |
| CAS DataBase Reference | 599-04-2(CAS DataBase Reference) |
| EPA Substance Registry System | Pantolactone (599-04-2) |
| Safety Statements | 22-24/25 |
| WGK Germany | 1 |
| F | 46091 |
| TSCA | Yes |
| HS Code | 29322090 |
Product Application of D-(-)-Pantolactone CAS#599-04-2
D-(-)-Pantolactone acts as a vital starting-material for synthesizing vitamin B5, also known as pantothenic acid, and gets employed across multiple industrial sectors.
Pharmaceutical sector：It works as an essential synthetic precursor to prepare D-calcium pantothenate and D-panthenol, the provitamin-B5 substance commonly added into different medicinal preparations.
Cosmetic and daily-care manufacturing：The compound helps produce humectants and skin-softening raw materials for diverse skincare and cosmetic goods.
Food and animal-feed additives：Its processed derivative D-calcium pantothenate is widely applied in nutrition supplements and livestock feed. It facilitates nutrient uptake and metabolism for human bodies and farm-raised creatures.
