Product Description of (S)-(+)-Mandelic Acid CAS#17199-29-0
(S)-(+)-Mandelic Acid is a chiral aromatic carboxylic acid with molecular formula C₈H₈O₃ and molecular weight 152.15. It appears as white or off-white crystalline powder, slightly soluble in water and freely soluble in ethanol, methanol and other polar organic solvents.
This chiral building block has stable optical activity under proper storage, with no racemization easily occurring. It can participate in esterification, salt formation and condensation reactions to prepare chiral derivatives. It is widely applied as a key raw material for chiral pharmaceutical synthesis.
(S)-(+)-Mandelic Acid Chemical Properties
| Melting point | 131-134 °C(lit.) |
| alpha | 155 º (c=2 , H2O) |
| Boiling point | 234.6°C (rough estimate) |
| density | 1.341 |
| refractive index | 153.5 ° (C=1, H2O) |
| Fp | >190°C |
| storage temp. | Store below +30°C. |
| solubility | Methanol (Slightly), Water (Sparingly, Heated) |
| form | Crystalline Powder |
| pka | 3.41±0.25(Predicted) |
| color | White to beige-brown |
| PH | 2.1 (60g/l, H2O, 20℃) |
| optical activity | [α]20/D +153±5°, c = 5% in H2O |
| Water Solubility | 100 g/L (25 ºC) |
| Sensitive | Light Sensitive |
| BRN | 2208678 |
| Stability: | Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents, strong reducing agents. |
| LogP | 0.550 (est) |
| CAS DataBase Reference | 17199-29-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzeneacetic acid, «alpha»-hydroxy-, (s)-(17199-29-0) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.S)- (17199-29-0) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-37/39-26-36 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29181980 |
Product Applications of (S)-(+)-Mandelic Acid CAS#17199-29-0
(S)-(+)-Mandelic Acid serves as a critical chiral intermediate for pharmaceutical and fine chemical industries. It is commonly used for synthesizing many chiral drugs, such as anti-infective agents and cardiovascular medicines. It also acts as a chiral resolving agent for the separation of racemic mixtures in asymmetric synthesis. In analytical chemistry, it can be applied for chiral identification and chromatographic resolution.
Besides pharmaceutical synthesis, it is used for developing chiral agrochemicals and functional fine chemicals. It is suitable for laboratory research, pilot scale production and industrial manufacturing of chiral compounds.
